Artisan Technology Group Quest 210 Specifications

Artisan Technology Group is your source for quality new and certied-used/pre-owned equipment• FAST SHIPPING AND DELIVERY• TENS OF THOUSANDS OF IN-S

Figure 5. Using the RV mount as a fulcrum, twist the RV to "break it free" from the Lower Drain Manifold male RV fitting and "twist-up

Figure 7. Remove the RV from the holder With your fingers, remove the RV from the Reactor Unit (Figure 7) Using a sharp pair of scissors, cut the top

RV Installation Slide ten 5 mL RVs between the aluminum heating plate and spring loaded insulators on the Reactor Unit. Press them down over the male

4. Check that the vessels are fully seated over the male Teflon RV fittings of the Lower Drain Manifold. If the vesseIs are seated properly, the tops

Figure 11. Quest Controller Unit display Place a single magnet mixer into each RV with the fin facing downward. Use the external hand magnet found in

Tm both Manifold Control Valves to "CLOSED" Drain Gas Metered Gas Solvent Closed Vent @- Closed Utility 1 Utility 2 Unscrew the Solvent B

2. Close the Upper Manifold by first turning the left Manifold Control Valve to "CLOSED", then turn the right Manifold Control Valve to &q

Press the Right or Left soft keys (',) to select the % Upward parameter (the amount of time the agitation bar remains in the up most position exp

Raise the handle so the Lower Manifold Drain Valves are closed. Add -4 mL DCM to the RVs by turning the Manifold Control Valves to "SOLVENT"

8. Move the agitator up by pressing the Agitation UP soft key located to the right of the Quest Controller Unit display. 9. Turn the Manifold Control

ARGONAUT TECHNOLOGIES Quest 21 0: User Tutorial R'OH or Et SLEt H PS-DES A (6equiv I R' R~ 7 mol% RhCI(PPh3)3 NMP (3 mL), 60°C, 3 h (1 50 mg

H. Addition of Reagent Under Nitrogen to the Reaction Vessels 1. Adjust the Metered Gas Needle Valve located on the top of the Quest Reactor Unit unti

On the Quest Controller Unit press the MODE soft key located below the LCD display until the Agitation menu is displayed. Set parameters as follows:

9. The heaters will shut off when the timer runs out and the RVs will begin cooling to ambient temperature. ----------------- A (ON) B (OFF) SET 60.0

h. Install the bottle cap assembly onto the 4L bottle of NMP. Ensure the Teflon bottle seal is placed in the bottleneck and tighten the bottle cap.

111. CleavageIScavenger of the Resin and Product Collection Cleavage solution (0.4 M HFIPyridine in THF, 4 mL) is added to the washed resin using a sy

Turn the agitation on by pushing the Agitation ON soft key located to the right side of the Quest Controller Unit display. If solvent is splashing up

bottom of the Lower Manifold. The silver buttons will snap out to verify that the collection tray is locked into position. 5. Ensure that each Teflon

c. On the Quest Controller Unit press the MODE soft key located below the LCD display until the Agitation menu is displayed. Set the agitation parame

1V. Cleaning the Quest (Maintenance) and Sample Work UpIAnalysis To ensure the Quest 2 10 is ready for the next synthesis it is recommended to flush t

B. Sample Work Up 1. Using a Savant SpeedVac (Model SS620DDA SpeedVac or equivalent), evaporate the solvent from the 20 mL scintillation vials contain

pGolidinemethanol 1 -na~hthaleneethanol I Aldrich I FW 172.23 1 206 mg Material ArgoCaps (PS-DES) Wilkinson's catalyst Chlorotris(triphenylphosph

C. IR and GC Product Analysis Infrared Analysis Infrared spectra were recorded on a Nicolet Impact 41 0 spectrometer equipped with an InspectIR micros

ame~r~usue~~o~ Figure 16. PS-DES Infrared Spectra Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.

agUey1WSUEJ 1 % Figure 17. PS-DES-OR Infrared Spectra Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisa

Sorred Ey Xrrltiplier Dilution Totals : Figure 18.-Ana2p5is of I-(2-methoxybenzoyl)-2-pyrr~lidinemethanol Artisan Technology Group - Quality Instrumen

Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

=========----======================================-----============= Injection Dzte : 1/22/98 8 :21:53 PM Seq. Line : 13 Sample Nane .. Vial : 98 A-c

Vial- : 99 Fisure 21. Analysis of pia and roster one Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisa

Figure 22. Analysis of 4-biph~nvlmethanol Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Artisan Technology Group is your source for quality new and certied-used/pre-owned equipment• FAST SHIPPING AND DELIVERY• TENS OF THOUSANDS OF IN-S

polycarbonate capsules (ArgoCaps) are placed into the RVs and washed three times with 4 mL of dichloromethane (DCM). The efficient removal of the ca

I AlcohollCarbonyl AlcohoVCarbonyl Structure Amount 1 1 -naphthaleneethanol 206 mgl 4 rnL NMP 2.2-diphenylethanol Ph 238 mgl ho H 4 rnL NMP Ph 218

Drain I Figure 2. Quest 210 Reactor Unit Installation of an Oil Bubbler and Purging the System - This synthesis requires an oil bubbler be installed i

Figure 3. Location of Manifold Controls and Utility Ports Once the oil bubbler is installed, ensure that it is functioning properly by doing th

using the white Teflon Drain Lever provided with the Quest to drain all I0 RVs in parallel. Drain Gas Metered Gas Utility 1 Utility 2 Leaving the Low

D. RV Removal & Instrument Cleaning 1. To remove the RVs from Side A (RVs 1-10) use the following protocol. a. Position the rotating lever on th